Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-2-cyanoacetamide | HCID 98341 | — |
| 반응물 | 6-Isothiocyanatoquinoline | HCID 13718422 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide | HCID 86703376 | 65.4% |
반응 단계
A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102637B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-c7a2e6ea4fa742208557da471a08eaa9 |
| 출처 메모 | uspto-grants-2015_08 |