2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

HRID 512547

반응식

HRID 512547 반응식
[N:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]=[CH:6][CH:5]=2)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]

참가 물질

4

반응물 2

HCID 983412-Amino-2-cyanoacetamideHCID 114993404-Isothiocyanatoquinoline

생성물 1

HCID 867033825-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

후처리

  1. temperaturewas refluxed for 90 min
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe resulting solids were collected
  4. washwashed with EtOAc

출처 및 근거

ORD 기록
ord-dd0b882fa8f8490fa1dd59d7dfe7fa8d
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102637B2

연결된 노트

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