1-(4-Bromo-3,5-dimethoxyphenyl)ethanol → 1-(4-Bromo-3,5-dimethoxyphenyl)ethan-1-one
반응식
[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([CH:10]([OH:12])[CH3:11])=[CH:4][C:3]=1[O:13][CH3:14]>C(Cl)Cl.O=[Mn]=O>[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10](=[O:12])[CH3:11])=[CH:4][C:3]=1[O:13][CH3:14]참가 물질
4
실험 절차
To a solution of 1-(4-bromo-3,5-dimethoxyphenyl)ethanol (10.8 g, 41.1 mmol) in anhydrous CH2Cl2 (150 mL) was added MnO2 (48 g, 552 mmol). After the mixture was placed under a drying tube and stirred at room temperature for 22 hours, it was filtered through a pad of Celite and silica gel and rinsed with EtOAc. Concentration of the filtrate in vacuo gave 1-(4-bromo-3,5-dimethoxyphenyl)ethanone as a white solid (10.3 g, 97% yield). The product was used without further purification.
후처리
- customAfter the mixture was placed under a drying tube
- filtrationit was filtered through a pad of Celite and silica gel
- washrinsed with EtOAc
출처 및 근거
- ORD 기록
- ord-aee42a4fc46d4d7ca7299bdaa4b4563e
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102643B2
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