Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 51315생성일: 2026년 10월 25일
5-Methylcyclohexane-1,3-dione → 3-(3-Carbomethoxy-2-bromoanilino)-5-methyl-cyclohex-2-en-1-one
https://huagongshe.com/reaction/51315
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Methylcyclohexane-1,3-dione | HCID 458095 | — |
| 반응물 | Methyl 3-amino-2-bromobenzoate | HCID 13574117 | — |
| 생성물 | 3-(3-Carbomethoxy-2-bromoanilino)-5-methyl-cyclohex-2-en-1-one | HCID 22740202 | 67% |
반응 단계
A mixture of methyl 2-bromo-3-aminobenzoate (10.2 g, 44.3 mM) and 5-methyl-1,3-cyclohexanedione (6.15 g, 48.7 mM) was heated at 125° C. under a stream of nitrogen for 1.5 hours. The resultant solid was triturated with ethyl acetate to afford 9.98 g (67%) of 3-(3-carbomethoxy-2-bromoanilino)-5-methyl-cyclohex-2-en-1-one. 1H NMR (CDCl3) δ7.55 (m, 2H), 7.35 (dd, J=8 and 8 Hz, 1H), 6.4 (bs, 1H), 5.55 (s, 1H), 3.95 (s, 3H), 2.6-2.0 (m, 5H), 1.15 (d, J=7 Hz, 3H). MS (ES) m/e 338, 340.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06713645B1 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-f382097c534844329b36ac624e9ee62f |
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| 출처 메모 | uspto-grants-2004_03 |
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