참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Amino-3-chloropyrazine | HCID 276224 | — |
| 반응물 | Methyl 3-Bromopyruvate | HCID 352524 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Methyl 8-chloroimidazo[1,2-A]pyrazine-2-carboxylate | HCID 71743177 | 70.7% |
반응 단계
To a solution of 3-chloropyrazin-2-amine (52 g, 401 mmol) in acetonitrile (750 mL) under N2 was added sodium bicarbonate (67.4 g, 803 mmol), and then methyl bromopyruvate (97 mL, 803 mmol). The mixture was then heated to 80° C. for 4 hours and then cooled to r.t. The reaction was then diluted water (2200 mL) and stirred for 30 minutes. The resulting solids were filtered, azeotroped with EtOAc (2 L), and dried overnight at 40° C. under vacuum and nitrogen sweep to give the title compound (60 g). LRMS (ESI) calc (M+H)+=212.0. found 212.0
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09102673B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-32b09f46a1bf42d2b54a87d4ee296622 |
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| 출처 메모 | uspto-grants-2015_08 |
|---|
