Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride
반응식
[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:23])=[O:5]참가 물질
5
실험 절차
To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.
후처리
- custom(vigorous bubbling) for 4 h
- concentrationconcentrated to an oily solid which
- customafter overnight
- customdrying on high vacuum
출처 및 근거
- ORD 기록
- ord-7e8ac219a9984f6494b1041233e4e050
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102686B2
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