Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride

HRID 513218

반응식

HRID 513218 반응식
[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:23])=[O:5]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27366772-Chloro-3-(trifluoromethyl)benzoic acid

생성물 1

HCID 38276332-Chloro-3-(trifluoromethyl)benzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.

후처리

  1. custom(vigorous bubbling) for 4 h
  2. concentrationconcentrated to an oily solid which
  3. customafter overnight
  4. customdrying on high vacuum

출처 및 근거

ORD 기록
ord-7e8ac219a9984f6494b1041233e4e050
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102686B2

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