참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-Phenyl-cyclopropylamine | HCID 194549 | — |
| 반응물 | 4,6-Dichloronicotinamide | HCID 600044 | — |
| 용매 | 2-Oxopropiononitrile | HCID 69430 | — |
| 생성물 | 6-Chloro-4-(1-phenylcyclopropylamino)nicotinamide | HCID 86664541 | 36.5% |
반응 단계
To a suspension of 4,6-dichloronicotinamide (191 mg, 1 mmol) in AcCN (2 mL) was added 1-phenylcyclopropanamine (160 mg, 1.2 mmol) and DIPEA (0.213 mL, 1.2 mmol). The mixture was heated at 60° C. for 2 days. The mixture was concentrated and purified by column chromatography to give 6-chloro-4-(1-phenylcyclopropylamino)nicotinamide (105 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09102625B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-bf1fb13d2bfd4e1ab3635b34fda50fdf |
|---|
| 출처 메모 | uspto-grants-2015_08 |
|---|
