참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4,6-Dichloronicotinamide | HCID 600044 | — |
| 반응물 | (3-(Pyridin-2-yl)phenyl)methanamine | HCID 59151546 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 6-Chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide | HCID 86664551 | 43.5% |
반응 단계
To a solution of 4,6-dichloronicotinamide (73 mg, 0.38 mmol) in NMP (0.75 mL) was added (3-(pyridine-2-yl)phenyl)methanamine (77 mg, 0.42 mmol) and DIPEA (0.22 mL, 1.33 mmol). After stirring at 80° C. for 15 h, the mixture was added water, the resulting precipitate was collected by filtration to give 6-chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide (56 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09102625B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-e91be3ccec2d491cb3757dd53ea73e35 |
|---|
| 출처 메모 | uspto-grants-2015_08 |
|---|
