Tetrahydrofuran → 5-(6-bromonaphthalen-2-yl)-N1,N3-bis(4-methoxyphenyl)-N1,N3-diphenylbenzene-1,3-Diamine

HRID 513320

반응식

HRID 513320 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:10]2[CH:15]=[C:14](B3OC(C)(C)C(C)(C)O3)[CH:13]=[C:12]([N:25]([C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:11]=2)=[CH:5][CH:4]=1.[Br:46][C:47]1[CH:56]=[CH:55][C:54]2[C:49](=[CH:50][CH:51]=[C:52](Br)[CH:53]=2)[CH:48]=1.C([O-])([O-])=O.[K+].[K+].C1COCC1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O>[Br:46][C:47]1[CH:48]=[C:49]2[C:54](=[CH:55][CH:56]=1)[CH:53]=[C:52]([C:14]1[CH:15]=[C:10]([N:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH:11]=[C:12]([N:25]([C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:13]=1)[CH:51]=[CH:50]2

참가 물질

7

반응물 4

HCID 8028TetrahydrofuranHCID 11430Potassium CarbonateHCID 6405912,6-DibromonaphthaleneHCID 68193967N1,N3-bis(4-methoxyphenyl)-N1,N3-diphenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-diamine

생성물 1

HCID 681937475-(6-bromonaphthalen-2-yl)-N1,N3-bis(4-methoxyphenyl)-N1,N3-diphenylbenzene-1,3-Diamine

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 962Water용매

실험 절차

13.42 g of a product (yield: 66%) was obtained in the same manner as described in the synthesis method of intermediate 2-3 except that N1,N3-bis(4-methoxyphenyl)-N1,N3-diphenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-diamine (17.76 g, 30 mmol), 2,6-dibromonaphthalene (9.44 g, 33 mmol), Pd(PPh3)4 (1.04 g, 0.9 mmol), K2CO3 (12.44 g, 90 mmol), THF (90 mL), and water (45 mL) were used.

출처 및 근거

ORD 기록
ord-17559f20e43e4b8f8c2a43fb252975b4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102616B2

연결된 노트

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