HCID 86702665, 화합물 → HCID 14909484, 화합물

HRID 513332노트

반응식

HRID 513332 반응식
[CH3:1][S:2]([C:5]#[C:6][CH2:7][CH2:8][CH2:9]/[CH:10]=[CH:11]/[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:4])=[O:3]>ClC1C=CC=CC=1Cl>[CH3:1][S:2]([C:5]1[C:13]2[C:12](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[C:10]2[CH2:9][CH2:8][CH2:7][C:6]=12)(=[O:3])=[O:4]

참가 물질

3

반응물 1

HCID 86702665HCID 86702665, 화합물

생성물 1

HCID 14909484HCID 14909484, 화합물수율 78%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

반응 조건

온도
225 °C

실험 절차

To a 2-5 mL microwave irradiation vial equipped with a stir bar was added enyne 5f (0.050 g, 0.20 mmol) in o-dichlorobenzene (2.3 mL). The reaction was irradiated with stirring at 225° C. for 20 min until complete by TLC. The reaction turned golden in color. The crude product was purified by silica gel column chromatography (14 g silica cartridge, 0-15% ethyl acetate/hexanes) to yield naphthalene 6f as a colorless oil (0.038 g, 78%).

후처리

  1. customTo a 2-5 mL microwave irradiation
  2. customvial equipped with a stir bar
  3. customThe reaction was irradiated
  4. customThe crude product was purified by silica gel column chromatography (14 g silica cartridge, 0-15% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-9584545ed4ad4261ac12271b0784f6d3
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102703B2

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