참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 8-Methoxy-3-methylquinoline | HCID 13984286 | — |
| 용매 | Hydrogen Bromide | HCID 260 | — |
| 생성물 | 3-Methylquinolin-8-ol | HCID 4332281 | 83% |
반응 단계
47% HBr (10 ml) was added to 8-methoxy-3-methylquinoline (Intermediate 29) (500 mg, 2.80 mmol) and heated at 122° C. for 18 h. The reaction was cooled to room temperature, the pH adjusted with sodium carbonate solution to pH=7 and extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (150 mg, 83%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09102688B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-c3d07f806a224b27afb62b8d2a4d5e6f |
|---|
| 출처 메모 | uspto-grants-2015_08 |
|---|
