Glycerol → 8-Nitro-6-(trifluoromethoxy)quinoline
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[N+:1]([C:4]1[CH:10]=[C:9]([O:11][C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].O[CH2:17][CH:18]([CH2:20]O)O.[Na+].[N+](C1C=C(S([O-])(=O)=O)C=CC=1)([O-])=O>>[N+:1]([C:4]1[CH:10]=[C:9]([O:11][C:12]([F:13])([F:14])[F:15])[CH:8]=[C:7]2[C:5]=1[N:6]=[CH:20][CH:18]=[CH:17]2)([O-:3])=[O:2]참가 물질
4
실험 절차
In a similar fashion using route 10 general procedure 20, 2-nitro-4-(trifluoromethoxy)aniline (1.0 g, 4.50 mmol), glycerol (1.3 g, 13.96 mmol) and 3-nitrobenzenesulfonic acid sodium salt (1.32 g, 5.85 mmol), gave the title compound (1.1 g, 95%) which was used in the next step without purification.
출처 및 근거
- ORD 기록
- ord-30d260696aa243d9949bc7d10cac18e7
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102688B2
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