Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous Chloride → 8-Quinolinamine, 5-(trifluoromethyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | 8-Nitro-5-(trifluoromethyl)quinoline | HCID 68183100 | — |
| 촉매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | 85.5% |
반응 단계
In a similar fashion using route 1 general procedure 4, 8-nitro-5-(trifluoromethyl)quinoline (Intermediate 33) (820 mg, 3.39 mmol), tin (II) chloride (1.93 g, 10.2 mmol) and 6 N HCl (10 drops) gave the title compound (615 mg, 85%) which was used in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-975e25dcd1ed40b6afd70c4f19df1dfd |
| 출처 메모 | uspto-grants-2015_08 |