7-Chloro-4-methoxy-8-nitro-quinoline → 7-Chloro-4-methoxyquinolin-8-amine
반응식
[Cl:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]2[C:5]([C:6]([O:15][CH3:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1>[Pd].CCO>[Cl:1][C:2]1[C:11]([NH2:12])=[C:10]2[C:5]([C:6]([O:15][CH3:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
7-Chloro-4-methoxy-8-nitro-quinoline (Intermediate 69) (261 mg, 1.1 mmol) was treated with 10% palladium on carbon (11.6 mg, cat) in EtOH (20 ml) in a Parr pressure reaction system and placed under a hydrogen atmosphere at 5 Barr pressure whilst stirring overnight. The pressure was released and the catalyst removed by filtration through celite. The solvent was removed in vacuo to give the title compound (246 mg, 100%).
후처리
- customthe catalyst removed by filtration through celite
- customThe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-6fb5f34f3b7c420994def6d68139fd9f
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102688B2
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