Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonyl chloride → N-(7-Chloro-quinolin-8-yl)-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonyl chloride | HCID 7369 | — |
| 반응물 | 7-Chloroquinolin-8-amine | HCID 224784 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Pentane | HCID 8003 | — |
| 생성물 | N-(7-Chloro-quinolin-8-yl)-benzenesulfonamide | HCID 60164005 | 61.6% |
반응 단계
In a similar fashion using route 14 general procedure 27, 7-chloroquinolin-8-amine (Intermediate 52) (100 mg, 0.56 mmol), benzenesulfonyl chloride (110 mg, 0.67 mmol) and DMAP (cat.) gave the title compound (110 mg, 56%) after trituration from n-pentane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-35b5932c20fd43a2b738a1ac2df0dfee |
| 출처 메모 | uspto-grants-2015_08 |