Pyridine → 5-Methyl-pyridine-2-sulfonic acid quinolin-8-ylamide

HRID 513487

반응식

HRID 513487 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8](Cl)(=[O:10])=[O:9])=[N:6][CH:7]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)Cl>[N:12]1[C:17]2[C:16](=[CH:2][CH:3]=[CH:4][C:5]=2[NH:6][S:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)(=[O:10])=[O:9])[CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 1049PyridineHCID 122954635-Methylpyridine-2-sulfonyl chloride

생성물 1

HCID 681833825-Methyl-pyridine-2-sulfonic acid quinolin-8-ylamide수율 25%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (40 mg, 0.27 mmol), 5-methyl-pyridine-2-sulfonyl chloride 440 (79 mg, 0.41 mmol), pyridine (1.5 ml) DMAP (cat.) and DCM (2 ml) gave the title compound (21 mg, 25%) after purification by column chromatography with n-hexane/EtOAc (93:7) as the eluent.

출처 및 근거

ORD 기록
ord-311fe6dc3e554d51b0a165ecd488016c
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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