Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Pyridine-2-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Pyridine-2-sulfonyl Chloride | HCID 3787675 | — |
| 반응물 | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Pyridine-2-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide | HCID 60164194 | 31.7% |
반응 단계
In a similar fashion using route 14 general procedure 27, 5-trifluoromethyl-quinolin-8-ylamine (Intermediate 45) (125 mg, 0.58 mmol), pyridine-2-sulfonyl chloride (Intermediate 18) (125 mg, 0.70 mmol), pyridine (0.09 ml, 1.17 mmol), DMAP (cat.) and DCM (5 ml) gave the title compound (65 mg, 31%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-d0e2902fa3b040c2a9cfb93694e09d45 |
| 출처 메모 | uspto-grants-2015_08 |