Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2-Nitro-N-quinoxalin-5-yl-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| 반응물 | 5-Aminoquinoxaline | HCID 85494 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Nitro-N-quinoxalin-5-yl-benzenesulfonamide | HCID 68183354 | 56% |
반응 단계
In a similar fashion using route 14 general procedure 26, quinoxalin-5-ylamine (Intermediate 482) (540 mg, 3.7 mmol), 2-nitro-benzenesulfonyl chloride (986 mg, 4.46 mmol), pyridine (0.9 ml, 7.44 mmol) and DCM (10 ml) gave the title compound (679 mg, 56%) after purification by column chromatography with DCM as the eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-7512a3a30b974f92835ebd98f46493a2 |
| 출처 메모 | uspto-grants-2015_08 |