Trifluoromethanesulfonate → HCID 60164095, 화합물

HRID 513647노트

반응식

HRID 513647 반응식
[C:1]1([NH:7][CH2:8][C:9]2[C:18]([NH2:19])=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1([S:25](N2C=C[N+](C)=C2)(=[O:27])=[O:26])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[C:1]1([N:7]2[S:25](=[O:27])(=[O:26])[NH:19][C:18]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][N:16]=4)[CH:11]=[CH:10][C:9]=3[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150, 화합물HCID 681831547-Phenylaminomethyl-quinolin-8-ylamine2회

생성물 1

HCID 60164095HCID 60164095, 화합물수율 4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 7-phenylaminomethyl-quinolin-8-ylamine (Intermediate 206) (350 mg, 1.4 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (762 mg, 2.1 mmol) in MeCN (10 ml) was stirred at 0° C. then allowed to warm to room temperature overnight. The reaction mixture was concentrated in vacuo and the crude residue was purified by preparative HPLC (basic conditions) to give the title compound (18 mg, 4%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude residue was purified by preparative HPLC (basic conditions)

출처 및 근거

ORD 기록
ord-e3896450a3ab4be08919dc43894bb617
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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