Trifluoromethanesulfonate → HCID 60164096, 화합물

HRID 513652노트

반응식

HRID 513652 반응식
[NH2:1][CH2:2][C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.N1([S:19](N2C=C[N+](C)=C2)(=[O:21])=[O:20])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[CH2:2]1[C:3]2[CH:4]=[CH:5][C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[C:12]=2[NH:13][S:19](=[O:21])(=[O:20])[NH:1]1

참가 물질

5

반응물 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150, 화합물HCID 68183296HCID 68183296, 화합물2회

생성물 1

HCID 60164096HCID 60164096, 화합물수율 6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

7-Aminomethyl-quinolin-8-amine (Intermediate 211) (50 mg, 0.29 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (157 mg, 0.43 mmol) in MeCN (5 ml) was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo. The crude residue was purified by preparative HPLC (basic conditions) to give the title compound (4.5 mg, 6%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude residue was purified by preparative HPLC (basic conditions)

출처 및 근거

ORD 기록
ord-a81072e81dc74f008a55d7fc33eee212
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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