Water → 3-Fluoro-6-nitrobenzenesulfonic acid

HRID 513718노트

반응식

HRID 513718 반응식
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[O-:12][S:13]([O-:15])=[O:14].[Na+].[Na+].O>CCO>[F:8][C:6]1[CH:5]=[CH:4][C:3]([N+:9]([O-:11])=[O:10])=[C:2]([S:13]([OH:15])(=[O:14])=[O:12])[CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24437Sodium SulfiteHCID 679672,4-Difluoronitrobenzene

생성물 1

HCID 129043703-Fluoro-6-nitrobenzenesulfonic acid수율 22.6%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

In a similar fashion using route 39 general procedure 95, 2,4-difluoronitrobenzene (2.0 g, 12.0 mmol) in EtOH (24 ml) and Na2SO3 (3.6 g, 28 mmol) in EtOH:water (32 ml: 40 ml) at 70° C. for 14 h gave the title compound (0.6 g) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

출처 및 근거

ORD 기록
ord-acb9924702b04996ad46489128e3bbf2
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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