Water → 4-Fluoro-5-methyl-2-nitro-benzenesulfonic acid

HRID 513720

반응식

HRID 513720 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5](F)=[CH:4][C:3]=1[CH3:12].[O-:13][S:14]([O-:16])=[O:15].[Na+].[Na+].O>CCO>[F:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([S:14]([OH:16])(=[O:15])=[O:13])=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24437Sodium SulfiteHCID 2306581,4-Difluoro-2-methyl-5-nitrobenzene

생성물 1

HCID 866697664-Fluoro-5-methyl-2-nitro-benzenesulfonic acid수율 73.6%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

In a similar fashion using route 39 general procedure 95, 1,4-difluoro-2-methyl-5-nitrobenzene (1.2 g, 6.93 mmol) in EtOH (10 ml) and Na2SO3 (1.98 g, 15.7 mmol) in EtOH:water (40 ml:25 ml) at 70° C. for 16 h gave the title compound (1.2 g, 73%) which was used in the next step without purification.

출처 및 근거

ORD 기록
ord-51c1a3014a69401fa6314e5f4b249712
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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