Methylamine → HCID 68190286, 화합물
반응식
CO[C:3]([C:5]1[CH:22]=[C:21]2[C:8]([S:9](=[O:24])(=[O:23])[NH:10][C:11]3[C:20]2=[CH:19][CH:18]=[C:17]2[C:12]=3[N:13]=[CH:14][CH:15]=[CH:16]2)=[CH:7][CH:6]=1)=[O:4].[CH3:25][NH2:26]>>[CH3:25][NH:26][C:3]([C:5]1[CH:22]=[C:21]2[C:8]([S:9](=[O:23])(=[O:24])[NH:10][C:11]3[C:20]2=[CH:19][CH:18]=[C:17]2[C:12]=3[N:13]=[CH:14][CH:15]=[CH:16]2)=[CH:7][CH:6]=1)=[O:4]참가 물질
3
실험 절차
In a similar fashion using route 53 general procedure 122,6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid methyl ester 307 (20 mg, 0.058 mmol), methylamine (33% in EtOH; 4 ml, 0.58 mmol) at 100° C. gave the title compound (16 mg 84%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
후처리
- customat 100° C.
출처 및 근거
- ORD 기록
- ord-b216a7df5ccd4d078f706e58f527f700
- 출처 데이터셋
- uspto-grants-2015_08