Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-Chloro-6-fluorophenylisothiocyanate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thiophosgene | HCID 10040 | — |
| 반응물 | 2-Chloro-6-fluoroaniline | HCID 2734205 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | 2-Chloro-6-fluorophenylisothiocyanate | HCID 26599140 | 96.4% |
반응 단계
To a solution of 2-chloro-6-fluorobenzenamine (5.0 g, 34 mmol) in chlorobenzene (52 mL) was added carbonothioic dichloride (thiophosgene) (5.1 g, 45 mmol) and DMF (0.27 mL). The reaction mixture was refluxed for 2 h and then concentrated to leave the title compound as a brown oil (6.15 g), which was used in Step C without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09107412B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-9befb20dcda74fe7a217375152cf105d |
| 출처 메모 | uspto-grants-2015_08 |