Dimethylamine → 1-(2-Dimethylaminoacetyl)-7-nitro-1,2,3,4-tetrahydroquinoline

HRID 514277노트

반응식

HRID 514277 반응식
Cl[CH2:2][C:3]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[CH3:18][NH:19][CH3:20]>C1COCC1>[CH3:18][N:19]([CH3:20])[CH2:2][C:3]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 125783601-(Chloroacetyl)-7-nitro-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 569786941-(2-Dimethylaminoacetyl)-7-nitro-1,2,3,4-tetrahydroquinoline

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2-chloro-1-(7-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanone (1 g, 3.9 mmol) was dissolved in 10 ml of dry THF and 7.8 ml of a 1M solution of dimethylamine in THF (7.8 mmol) were added. This reaction mixture was stirred at ambient temperature for 24 h. The solvent was removed under reduced pressure and the residue was crystallized from diethyl ether to give the expected compound 2-(dimethylamino)-1-(7-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanone in the form of a brown solid (m.p. 130-132° C.).

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-cd2b27b1c68a47efa7c8d8fdd3eef707
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09107848B2

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