참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 2-methylacetoacetate | HCID 701 | — |
| 반응물 | 2-Hydrazinylpyridine-4-carbonitrile | HCID 20118714 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178433908 | HCID 178433908 | 47% |
반응 단계
A mixture of 2-hydrazinylpyridine-4-carbonitrile (134 mg, 1 mmol, PREPARATION 2) and 2-methyl-3-oxo-butyric acid ethyl ester (158 mg, 1.1 mmol) in EtOH (5 mL) and AcOH (1 mL) was stirred at 90° C. overnight. The reaction mixture was cooled, concentrated, and purified by flash column chromatography (CH2Cl2) to afford the title compound (100 mg, 47%) as an orange solid. [M+H] Calc'd for C11H10N4O, 215. Found, 215.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09107916B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-1bc84d3b06184c8582c335a76ca23ee2 |
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| 출처 메모 | uspto-grants-2015_08 |
|---|
