Ethyl 3-(2-fluorophenyl)-3-oxopropanoate → HCID 178510210, 화합물

HRID 514328

반응식

HRID 514328 반응식
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1)[NH2:2].[F:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18](=O)[CH2:19][C:20](OCC)=[O:21]>>[F:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[CH:19]=[C:20]([OH:21])[N:1]([C:3]2[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=2)[N:2]=1

참가 물질

3

반응물 2

HCID 296342Ethyl 3-(2-fluorophenyl)-3-oxopropanoateHCID 201187142-Hydrazinylpyridine-4-carbonitrile

생성물 1

HCID 178510210HCID 178510210, 화합물수율 48%

실험 절차

The title compound was prepared in 48% yield from 2-hydrazinylpyridine-4-carbonitrile (PREPARATION 2) and ethyl 3-(2-fluorophenyl)-3-oxopropanoate according to the procedure for the preparation of Example 3, part A. 1H NMR (300 MHz, DMSO-d6): δ 6.15-6.17 (1H, m), 7.13-7.41 (4H, m), 8.07-8.12 (1H, m), 8.34 (1H, s), 8.48-8.50 (1H, m), 11.64 (1H, s). [M+H] Calc'd for C15H9FN4O, 281. Found, 281.

출처 및 근거

ORD 기록
ord-78906bcb7fc946878e569f8147bccbba
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09107916B2

연결된 노트

불러오는 중…