1-Phenyl-2-propanol → Phenylacetone

HRID 514371

반응식

HRID 514371 반응식
[C:1]1([CH2:7][CH:8]([OH:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[C:1]1([CH2:7][C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 941851-Phenyl-2-propanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 7678Phenylacetone수율 85.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1-phenylpropan-2-ol (2.72 g, 20 mmol) in CH2Cl2 (20 mL) was added pyridinium chlorochromate (PCC, 5.4 g, 25 mmol) at 0° C. and the mixture was stirred for 3 h. The mixture was concentrated and purified by flash column chromatography (PE/EtOAc=20:1) to give the title compound (2.3 g, 84%) as a yellow oil.

후처리

  1. concentrationThe mixture was concentrated
  2. custompurified by flash column chromatography (PE/EtOAc=20:1)

출처 및 근거

ORD 기록
ord-1d69b9b3861e4ae3bdfff58d082611de
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09107916B2

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