3,4-Dichlorobenzyl alcohol → 2-[5-[(3,4-Dichlorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

HRID 514427

반응식

HRID 514427 반응식
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23]O)[CH:19]=[CH:20][C:21]=1[Cl:22]>>[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)[CH:19]=[CH:20][C:21]=1[Cl:22]

참가 물질

3

반응물 2

HCID 157283,4-Dichlorobenzyl alcoholHCID 178510213HCID 178510213, 화합물

생성물 1

HCID 867255522-[5-[(3,4-Dichlorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

실험 절차

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (3,4-dichlorophenyl)methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 5.12 (2H, s), 5.66 (1H, d, J=1.6 Hz), 7.20 (1H, d, J=2.0 Hz), 7.35 (1H, dd, J=1.2, 5.2 Hz), 7.40 (1H, d, J=8.0 Hz), 7.52 (2H, m), 7.98 (1H, s), 8.64 (1H, d, J=4.8 Hz). [M+H] Calc'd for C16H10C12N4O, 345. Found, 345.

출처 및 근거

ORD 기록
ord-7b795ba083b14ce4b9f1af4fa02e8e9b
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09107916B2

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