Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-[1-(4-Cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 2-[4-(2-Hydroxyethyl)pyrazol-1-yl]pyridine-4-carbonitrile | HCID 86725663 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[1-(4-Cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate | HCID 86725665 | 87% |
반응 단계
To a mixture of 2-[4-(2-hydroxyethyl)pyrazol-1-yl]pyridine-4-carbonitrile (700 mg, 3.3 mmol), Et3N (670 mg, 6.6 mmol) in DCM (15 mL) was added MeSO2Cl (410 mg, 3.6 mmoL) at 0° C., the mixture was then stirred for 2 hours at room temperature, water was added and extracted with DCM and concentrated give the title compound (830 mg, 87%). [M+H] Calc'd for C12H12N4O3S, 293. Found, 293.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09107916B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-7f3df3cd21434178b2c299853ed84ce7 |
| 출처 메모 | uspto-grants-2015_08 |