참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(4-fluorophenyl)-N-methylmethanamine | HCID 736860 | — |
| 반응물 | 2-[1-(4-Cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate | HCID 86725665 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 86725664 | HCID 86725664 | 50.3% |
반응 단계
To a mixture of 2-[1-(4-cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate (476 mg, 1.6 mmol) and (4-flouro-benzyl)-methyl-amine (444 mg, 3.2 mmol) in ACN (30 mL) at rt was added K2CO3 (4.5 g, 32 mmol) and KI (1.0 g, 6.2 mmol. The reaction mixture was heated to 80° C. and stirred overnight. Filtered, solvent removed and purified by prep-HPLC to give the title compound (270 mg, 50%). [M+H] Calc'd for C19H18FN5, 336. Found, 336.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09107916B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-86447b2a9d744996b4ac6bc4175d3280 |
|---|
| 출처 메모 | uspto-grants-2015_08 |
|---|
