4-Fluorobenzylic alcohol → 5-Fluoro-4-{2-fluoro-4-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine

HRID 514712노트

반응식

HRID 514712 반응식
[F:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([F:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])[CH:18]=2)[N:10]=1.[F:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][OH:36])=[CH:31][CH:30]=1>>[F:15][C:14]1[C:9]([C:3]2[CH:4]=[CH:5][C:6]([O:36][CH2:35][C:32]3[CH:33]=[CH:34][C:29]([F:28])=[CH:30][CH:31]=3)=[CH:7][C:2]=2[F:1])=[N:10][C:11]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][S:24]([CH3:27])(=[O:25])=[O:26])[CH:18]=2)=[N:12][CH:13]=1

참가 물질

3

반응물 2

HCID 680224-Fluorobenzylic alcoholHCID 867296154-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine2회

생성물 1

HCID 867296165-Fluoro-4-{2-fluoro-4-[(4-fluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine

실험 절차

Example 17 was prepared under similar conditions as described in the preparation of Example 16 using 4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine (Intermediate 16.2) and (4-fluorophenyl)methanol (ABCR GmbH & CO. KG). The batch was purified by preparative HPLC.

후처리

  1. customExample 17 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-7ff8dbb14662453b9b6623ebfffdfa19
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108926B2

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