Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-(5-bromopyridin-2-yl)-2-nitrobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2-Nitrobenzoyl chloride | HCID 11875 | — |
| 반응물 | 2-Amino-5-bromopyridine | HCID 70622 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(5-bromopyridin-2-yl)-2-nitrobenzamide | HCID 679218 | 77.9% |
반응 단계
A solution of 2-nitrobenzoyl chloride (3.70 g, 20 mmol, 1.0 equiv), 2-amino-5-bromopyridine (3.50 g, 1.0 equiv), pyridine (10 mL) in 25 mL of methylene chloride was stirred overnight. The volatile was evaporated, flash chromatography on silica gel gave N-(5-bromo-2-pyridinyl)-(2-nitro)phenylcarboxamide (5.02 g, 77%). MS found for C12H9BrN3O3 (M+H)+: 322.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09108922B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-422f7acf7e0c43b881d149c31781a1fa |
| 출처 메모 | uspto-grants-2015_08 |