Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous chloride dihydrate → 3-(2-Aminophenoxy)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 3-(2-Nitrophenoxy)benzonitrile | HCID 9194888 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(2-Aminophenoxy)benzonitrile | HCID 22596335 | 99% |
반응 단계
A solution of 3-(2-nitrophenoxy)benzonitrile (1.21 g, 5 mmol, 1.0 equiv) in 30 mL of EtOH was treated with SnCl2.2H2O (3.38 g, 3 equiv) at reflux for 4 h. The volatile was evaporated and the residue was redissolved in EtOAc, washed with saturated aqueous NaHCO3 and 1N NaOH. The organic layer was dried over MgSO4, filtered and evaporated to give 3-(2-aminophenoxy)benzonitrile (1.04 g, 99%). MS found for C13H11N2O (M+H)+: 211.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09108922B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-c9d7f97e42fd482ea06a7b38847420cf |
| 출처 메모 | uspto-grants-2015_08 |