Sodium Iodide → HCID 90447574, 화합물

HRID 514804노트

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HRID 514804 반응식
[CH2:1]([C:4]1([OH:17])[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[Na+].[I-].C[Si](C)(C)[C:22]([F:25])(F)[F:23].C1COCC1>C(Cl)Cl>[F:23][C:22]1([F:25])[CH2:3][CH:2]1[CH2:1][C:4]1([OH:17])[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 8028TetrahydrofuranHCID 552549(Trifluoromethyl)trimethylsilaneHCID 21955339Tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate

생성물 1

HCID 90447574HCID 90447574, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
80 °C

실험 절차

To a sealed tube was added tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate 11B (280 mg, 1.16 mmol), NaI (112 mg, 0.74 mmol), trimethyl(trifluoromethyl)silane (0.6 mL) and THF (10 mL), The tube was sealed, and then the mixture was stirred at 80° C. overnight. The resulting mixture was diluted with DCM, filtered, and the filtrate was concentrated in vacuo to give the crude product 11C which was used for next step without further purification. LC-MS: m/z 292.3 (M+H)+

후처리

  1. customThe tube was sealed
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-f0c4ce2059ae482e8ce3a2cfa05d0b89
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108921B2

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