Diethylamine → 2-[4-(4-chloro-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d)pyrimidin-5-yl)phenoxy]-N,N-diethylbenzylamine

HRID 51484노트

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HRID 51484 반응식
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[Cl:15][C:16]1[C:17]2[C:24]([C:25]3[CH:39]=[CH:38][C:28]([O:29][C:30]4[CH:37]=[CH:36][CH:35]=[CH:34][C:31]=4[CH:32]=O)=[CH:27][CH:26]=3)=[CH:23][N:22]([CH:40]3[CH2:44][CH2:43][O:42][CH2:41]3)[C:18]=2[N:19]=[CH:20][N:21]=1.[CH2:45]([NH:47][CH2:48][CH3:49])[CH3:46]>ClCCCl>[Cl:15][C:16]1[C:17]2[C:24]([C:25]3[CH:26]=[CH:27][C:28]([O:29][C:30]4[CH:37]=[CH:36][CH:35]=[CH:34][C:31]=4[CH2:32][N:47]([CH2:48][CH3:49])[CH2:45][CH3:46])=[CH:38][CH:39]=3)=[CH:23][N:22]([CH:40]3[CH2:44][CH2:43][O:42][CH2:41]3)[C:18]=2[N:19]=[CH:20][N:21]=1

참가 물질

5

반응물 3

HCID 8021DiethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 86589002(4-(4-chloro-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy]benzaldehyde

생성물 1

HCID 865890012-[4-(4-chloro-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d)pyrimidin-5-yl)phenoxy]-N,N-diethylbenzylamine

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Sodium triacetoxyborohydride (264 mg) was added to a mixture of 2-[(4-(4-chloro-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy]benzaldehyde (330 mg) and diethylamine (121 mg) in 1,2-dichloroethane in a vial (5 ml) and the vial septum sealed. The mixture was stirred at ambient temperature for 20 hours then quenched with saturated aqueous sodium bicarbonate solution (5 ml). The mixture was extracted with ethyl acetate to give 2-[4-(4-chloro-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d)pyrimidin-5-yl)phenoxy]-N,N-diethylbenzylamine.

후처리

  1. customthe vial septum sealed
  2. customthen quenched with saturated aqueous sodium bicarbonate solution (5 ml)
  3. extractionThe mixture was extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-1fa94fc079394ebda30b643864d0c238
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713474B2

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