4-Bromophenol → 2-(4-Bromophenoxy)benzonitrile

HRID 51485

반응식

HRID 51485 반응식
F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 678552-Fluorobenzonitrile

생성물 1

HCID 227364352-(4-Bromophenoxy)benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

A mixture of 2-fluorobenzonitrile (28.8 g), 4-bromophenol (36.9 g), potassium carbonate (58.9 g) and dimethylformamide (30 ml) was heated with stirring under nitrogen at 120° C. for 5 hours. The mixture was allowed to stand overnight at ambient temperature and then partitioned between ethyl acetate and water. The organic layer was separated, washed, dried and evaporated to give an oil which solidified on standing. The solid was triturated with petroleum ether b.p. 40-60° C. and filtered to give 2-(4-bromophenoxy)benzonitrile.

후처리

  1. temperaturewas heated
  2. waitto stand overnight at ambient temperature
  3. custompartitioned between ethyl acetate and water
  4. customThe organic layer was separated
  5. washwashed
  6. customdried
  7. customevaporated
  8. customto give an oil which
  9. customThe solid was triturated with petroleum ether b.p. 40-60° C.
  10. filtrationfiltered

출처 및 근거

ORD 기록
ord-55b7fb0c0aa44265ba7561577d290abe
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713474B2

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