Lithium aluminum hydride → 2-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)ethan-1-amine

HRID 514888노트

반응식

HRID 514888 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[C:9]#[N:10])=[CH:4][CH:3]=1.[AlH4-].[Li+]>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:9][NH2:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 28112Lithium aluminum hydrideHCID 24276601HCID 24276601, 화합물

생성물 1

HCID 163948842-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)ethan-1-amine수율 30%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (4-Chloro-phenyl)-pyrrolidin-1-yl-acetonitrile (3.52 g, 15.2 mmol; in Tetrahydrofuran (96 mL) was added Lithium tetrahydroaluminate (1225 mg, 32.28 mmol) and the reaction was refluxed over night. The reaction was quenched with H2O (1.22 ml), 2M NaOH (aq) (1.22 ml) and H2O (2.44 ml). The solid was filtered off and the reaction was concentrated, to yield 2-(4-chlorophenyl)-2-(pyrrolidin-1-yl)ethanamine (1.14 g, 30% yield).

후처리

  1. temperaturethe reaction was refluxed over night
  2. customThe reaction was quenched with H2O (1.22 ml), 2M NaOH (aq) (1.22 ml) and H2O (2.44 ml)
  3. filtrationThe solid was filtered off
  4. concentrationthe reaction was concentrated

출처 및 근거

ORD 기록
ord-56aa4b0e126b488fa14fb0037972f7aa
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108938B2

반응 노트

불러오는 중…