3-Bromo-2-methylbenzoic Acid → (3-Bromo-2-methylphenyl)methanol

HRID 515103

반응식

HRID 515103 반응식
[Br:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:11])=[C:4]([CH2:5][OH:6])[CH:8]=[CH:9][CH:10]=1

참가 물질

3

반응물 1

HCID 27355903-Bromo-2-methylbenzoic Acid

생성물 1

HCID 10035697(3-Bromo-2-methylphenyl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-bromo-2-methyl benzoic acid (35 g, 160 mmol) in THF (200 mL) was added borane THF complex (1.0 M, 210 mL, 210 mmol). The mixture was allowed to stir for 24 hours. The reaction was quenched with water. The solvent THF was removed under reduced pressure. The resulting solid was dissolved in ethyl acetate (500 mL), washed with 1N hydrochloric acid, saturated sodium bicarbonate, and brine. The combined organic layers were dried over sodium sulfate and concentrated to afford (3-bromo-2-methylphenyl)methanol.

후처리

  1. customThe reaction was quenched with water
  2. customThe solvent THF was removed under reduced pressure
  3. dissolutionThe resulting solid was dissolved in ethyl acetate (500 mL)
  4. washwashed with 1N hydrochloric acid, saturated sodium bicarbonate, and brine
  5. dry with materialThe combined organic layers were dried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f78fa7cad65f4569865267fde3203bcf
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108947B2

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