4-Bromo-2,6-difluorobenzonitrile → 4-Bromo-2-fluoro-6-methoxybenzonitrile

HRID 515191노트

반응식

HRID 515191 반응식
[Br:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1.[CH3:12][O-:13].[Na+]>O1CCCC1>[Br:1][C:2]1[CH:9]=[C:8]([O:13][CH3:12])[C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 27569164-Bromo-2,6-difluorobenzonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 574422094-Bromo-2-fluoro-6-methoxybenzonitrile수율 53.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-bromo-2,6-difluoro-benzonitrile (15.0 g, 68.8 mmol) in tetrahydrofuran (150 ml) is added sodium methoxide (4.5 g, 82.6 mmol) at room temperature and the mixture is stirred for 16 h. The reaction mixture is concentrated under reduced pressure and the resulting solid is purified by column chromatography (silica gel, 5% ethyl acetate/hexane) to obtain 4-bromo-2-fluoro-6-methoxy-benzonitrile (8.5 g, 36.9 mmol, 53%).

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe resulting solid is purified by column chromatography (silica gel, 5% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-79b6a41160804129bd0f086abf770979
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108936B2

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