Ethyl 2-chloro-1,3-thiazole-5-carboxylate → Ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate

HRID 515251노트

반응식

HRID 515251 반응식
Cl[C:2]1[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=1.[NH2:12][C:13]1[CH:18]=[C:17]([Br:19])[N:16]=[C:15]([CH3:20])[N:14]=1>>[Br:19][C:17]1[N:16]=[C:15]([CH3:20])[N:14]=[C:13]([NH:12][C:2]2[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=2)[CH:18]=1

참가 물질

3

반응물 2

HCID 19017727Ethyl 2-chloro-1,3-thiazole-5-carboxylateHCID 569657194-Amino-6-bromo-2-methylpyrimidine

생성물 1

HCID 49821807Ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate수율 75.5%

실험 절차

Prepared from ethyl 2-chlorothiazole-5-formate and Compound 9: ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate was yielded (yield: 75.5%).

출처 및 근거

ORD 기록
ord-11832d28fa804ee8b6b4032b40e5a2e9
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108954B2

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