Trifluoroacetic acid → 2-Fluoro-4-(piperidin-4-ylmethyl)aniline

HRID 515290노트

반응식

HRID 515290 반응식
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[F:22].FC(F)(F)C(O)=O>ClCCl>[F:22][C:3]1[CH:4]=[C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH:20]=[CH:21][C:2]=1[NH2:1]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67193052Tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate

생성물 1

HCID 671959362-Fluoro-4-(piperidin-4-ylmethyl)aniline수율 118.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate (6.49 mmol, 2 g) was dissolved in dichloromethane (5 mL). Trifluoroacetic acid (3 mL) was added and the reaction mixture stirred at room temperature for 30 minutes. The reaction mixture was purified by SCX chromatography to give the intermediate 2-fluoro-4-(piperidin-4-ylmethyl)aniline (1.6 g) as a colourless oil.

후처리

  1. customThe reaction mixture was purified by SCX chromatography

출처 및 근거

ORD 기록
ord-76db2c94a0b54794bb75234748a516d8
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108939B2

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