Trifluoroacetic acid → HCID 61684683, 화합물

HRID 515317노트

반응식

HRID 515317 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH:12]1[CH2:11][CH2:10][CH:9]([S:8][C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][CH:4]=2)[CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 18538812Tert-butyl 4-(4-aminophenylthio)piperidine-1-carboxylate

생성물 1

HCID 61684683HCID 61684683, 화합물수율 72%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 4-(4-aminophenylthio)piperidine-1-carboxylate (9.27 mmol, 2.859 g) was dissolved in dichloromethane (10 ml) and trifluoroacetic acid (10 mL) and the reaction mixture stirred at room temperature for 30 minutes. The reaction mixture was purified via SCX column chromatography to afford the title compound (1.39 g).

후처리

  1. customThe reaction mixture was purified via SCX column chromatography

출처 및 근거

ORD 기록
ord-e56cebc3698644ac9c0709153577fa9b
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108939B2

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