Cyclopropanemethanamine → Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

HRID 515324노트

반응식

HRID 515324 반응식
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.[N:6]([C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)=[C:7]=[O:8]>ClCCl>[CH:1]1([CH2:4][NH:5][C:7](=[O:8])[NH:6][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 75646CyclopropanemethanamineHCID 589805Ethyl 4-isocyanatobenzoate

생성물 1

HCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate수율 107.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To cyclopropylmethanamine (57.5 mmol, 4.99 mL, 4.09 g) in dichloromethane (40 mL) was added to ethyl 4-isocyanatobenzoate (52.3 mmol, 10 g) in dichloromethane (45 mL) and the reaction stirred overnight. The reaction was then concentrated under reduced pressure to give the title compound (14.7 g).

후처리

  1. concentrationThe reaction was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8687af6912874e2b8c73f7b33c2aea4b
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108939B2

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