Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Reserpine → 2-(3-Chloro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Reserpine | HCID 5770 | — |
| 반응물 | 4-Bromo-2-chloro-1-phenoxybenzene | HCID 22736309 | — |
| 반응물 | 2-Phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzonitrile | HCID 22736340 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(3-Chloro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 22736217 | 81% |
반응 단계
The title compound (472 mg, 81%) was prepared from 4-bromo-2-chloro-1-phenoxybenzene (500 mg, 1.77 mmol) in a similar manner to that described for the preparation 2-phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 7.75(s, 1H), 7.60 (d, 1H), 7.42(t, 2H), 7.21(t, 1H), 7.02 (m, 3H), 1.30(s, 12H); RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 15.53 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713474B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-ff11ae08660144859675c170f1c5e7a9 |
| 출처 메모 | uspto-grants-2004_03 |