Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Reserpine → 4-Bromo-2-fluoro-1-phenoxybenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Reserpine | HCID 5770 | — |
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | 4-Bromo-2-fluorophenol | HCID 2724981 | — |
| 반응물 | 4-Bromo-2-chloro-1-phenoxybenzene | HCID 22736309 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-Bromo-2-fluoro-1-phenoxybenzene | HCID 22736316 | 33% |
반응 단계
The title compound was prepared in a 33% yield from 4-bromo-2-fluorophenol and phenyl boronic acid in a manner similar to that described for the preparation of 4-bromo-2-chloro-1-phenoxybenzene: 1H NMR (DMSO-d6, 400 MHz) δ 7.75(dd, 1H), 7.40(m, 3H), 7.15(m, 2H), 7.01(dd, 2H); MS MH+267.2; RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 13.57 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713474B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-57ff8a9bd30246adb911baf6f2074ac0 |
| 출처 메모 | uspto-grants-2004_03 |