Triacetoxyperiodinane → 5-Bromo-2-chloropyridine-3-carbaldehyde
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[C:5]([Cl:8])=[N:6][CH:7]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[N:6][C:5]([Cl:8])=[C:4]([CH:3]=1)[CH:9]=[O:10]참가 물질
4
실험 절차
To a solution of (5-bromo-2-chloropyridin-3-yl)methanol (6.8 g, 30.6 mmol) in DCM (200 mL), was added Dess-Martin periodinane (32.4 g, 76.6 mmol) at 0° C. The resulting mixture was stirred at room temperature for 12 h. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel (0 to 30% EtOAc in petroleum ether) to afford 5.05 g of 5-bromo-2-chloronicotinaldehyde. LCMS [M+H]+ 221.1.
후처리
- concentrationThe reaction mixture was concentrated in vacuo
- customthe residue was purified by column chromatography on silica gel (0 to 30% EtOAc in petroleum ether)
출처 및 근거
- ORD 기록
- ord-732957e950934f0ba4b72d11177a6eb6
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09108944B2
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