2-Methylquinoline → 2-Methyl-1,2,3,4-tetrahydroquinoline
반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.C(O)=O.C(N(CC)CC)C>C(Cl)Cl>[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1참가 물질
4
반응 조건
- 온도
- -10 °C
실험 절차
In 60 ml of methylene chloride, 1.00 g of 2-methylquinoline was dissolved, and the catalyst-containing mixture was added. After cooling to −10° C., 8.4 ml of a mixed solvent of formic acid/triethylamine (molar ratio: 5/2) was added dropwise, and the mixture was stirred at the same temperature overnight to give 2-methyl-1,2,3,4-tetrahydroquinoline. The S-enantiomer was in excess and the optical purity was 86.4% ee.
후처리
- additionthe catalyst-containing mixture was added
출처 및 근거
- ORD 기록
- ord-9bdefd527d6d49ba9a1d022f89580b96
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09108986B2
반응 노트
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