1,3-Benzodioxole-5-carboxaldehyde, 6-bromo- → 6-[4-(Ethoxycarbonyl)-1-methyl-1H-pyrrol-2-yl]-1,3-benzodioxole-5-carboxylic acid

HRID 515867

반응식

HRID 515867 반응식
C[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].N1[CH:16]=[CH:15][C:14]([C:17]([O:19]CC)=[O:18])=[CH:13]1.Br[C:23]1C=C(Cl)C=CC=1C=O.BrC1C(C=O)=C[C:36]2[O:40][CH2:39][O:38][C:37]=2C=1>>[CH2:10]([O:9][C:7]([C:6]1[CH:5]=[C:4]([C:15]2[C:14]([C:17]([OH:19])=[O:18])=[CH:13][C:36]3[O:40][CH2:39][O:38][C:37]=3[CH:16]=2)[N:3]([CH3:23])[CH:2]=1)=[O:8])[CH3:11]

참가 물질

5

반응물 4

HCID 950621,3-Benzodioxole-5-carboxaldehyde, 6-bromo-HCID 136747Ethyl 2-methyl-3-pyrrolecarboxylateHCID 13070719Ethyl 1H-pyrrole-3-carboxylateHCID 131547102-Bromo-4-chlorobenzaldehyde

생성물 1

HCID 1178337706-[4-(Ethoxycarbonyl)-1-methyl-1H-pyrrol-2-yl]-1,3-benzodioxole-5-carboxylic acid

실험 절차

The procedure is in accordance with the process of Preparation 1, replacing, on the one hand, the ethyl 2-methyl-1H-pyrrole-3-carboxylate used in Step A by ethyl 1H-pyrrole-3-carboxylate and, on the other hand, the 2-bromo-4-chlorobenzaldehyde used in Step B by 6-bromo-1,3-benzodioxole-5-carbaldehyde.

후처리

  1. customThe procedure is in accordance with the process of Preparation 1

출처 및 근거

ORD 기록
ord-e8b501bc41db4ed08218ed7fd4dd2bc7
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108983B2

연결된 노트

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