Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenol → 4-Bromo-2-phenoxybenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Reserpine | HCID 5770 | — |
| 반응물 | 5-Bromo-2-fluorobenzaldehyde | HCID 736327 | — |
| 반응물 | 2-(3-Bromophenoxy)benzonitrile | HCID 28602353 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-Bromo-2-phenoxybenzaldehyde | HCID 16413429 | 46% |
반응 단계
The title compound was prepared in a 46% yield from 5-bromo-2-fluoro-benzaldehyde and phenol in a manner similar to that described for the preparation of 5-bromo-phenoxybenzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 10.32(s, 1H), 7.92(s, 1H), 7.81(d, 1H), 7.46(t, 2H), 7.27(t, 1H), 7.18(d, 2H), 6.90(d, 1H) RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 13.08 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713474B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-34160c193bba4f8993363aa30d6abc90 |
| 출처 메모 | uspto-grants-2004_03 |